Effects of Sleep Deprivation on Serum Cytokine Levels of Rats / 中国心理卫生杂志

Objective: To investigate the effects of paradoxical sleep deprivation (SD) on serum cytokine levels of Sprague-Dawley rats Method:Paradoxical sleep deprivation was induced in male rats by housing them on small platforms over water Controls were housed either in normal cages (CC) or in tanks with large platforms (TC) After SD for different lengths of time, serum levels of IL-2, 6, 8, TNF-? and cortisol of all groups were measured by double antibodies radio-immune assay Results: Serum level of TNF-? and cortisol of SD24h group were higher than that of CC (P